The contamination of water resources by hazardous organic compounds is becoming severe worldwide. In this study, the adsorptive removal of atrazine (ATZ) and diuron (DUR), two widely used herbicides, from water by polyaniline-derived carbons (PDCs) was investigated for the first time, under various conditions. A selected PDC, fabricated at optimum conditions, i.e., by pyrolysis at 800?°C (and labeled PDC(800)), showed remarkable adsorptivity for both herbicides, that is, 7.7 and 11.3 times the maximum adsorption capacity (Q0) for ATZ and DUR, respectively, compared to activated carbon (AC). Or, the Q0 values of PDC(800) for ATZ and DUR were 943 and 884?mg/g, respectively; however, the Q0 values of AC were only 123 and 78.0?mg/g, respectively. Moreover, the optimum adsorbent PDC(800) had 4.5 and 3.1 times Q0 that of the best adsorbent, that showed the highest performances, so far, for ATZ and DUR, respectively. Plausible adsorption mechanisms were suggested based on the porosity and the adsorption in a wide pH range. The new adsorbent was reusable via simple solvent washing. Based on its remarkable adsorption performance and facile reusability, PDC(800) can be considered a promising adsorbent to remove herbicides such as ATZ and DUR from contaminated water. BACKGROUND Noticeable in-toeing gait is present in most children with internal rotational malalignment and often a reason to consult an orthopedic specialist. The risk of tripping may be higher for these patients. RESEARCH QUESTION The aim of this study was to determine compensatory mechanisms adopted by children with internal rotational deformities to avoid tripping and falling during walking and running. METHODS Sixty-nine patients between 5-18 years with idiopathic internal rotational malalignment were retrospectively included and subdivided into three groups 18 patients with internal tibial torsion (ITT), 25 patients with internal femoral torsion (ITF) and 26 patients with both (ITB). Twenty-two typically developing age-matched children (TD) were analyzed for comparison. Three-dimensional gait data were evaluated. ANOVA's on two factors, group (ITT, ITF, ITB, TD) and movement (walking, running) with post-hoc t-tests were used to identify significant differences between groups. https://www.selleckchem.com/products/at13387.html RESULTS All groups had significantly greater step width than TD during walking (P ? .002) and all torsional groups had significantly greater step width during running (P ? .001). Similarly, all torsional groups showed greater peak ankle dorsiflexion in swing during running than TD (P ? .006). Only the ITT group showed significantly greater external hip rotation than TD. When compared to TD, the ITF and ITB group had a significantly lower hip abduction moment in stance during running, but not for walking (P ? .032). SIGNIFICANCE Compensatory mechanisms in children with internal rotational deformities were mostly dependent on the location of rotational malalignment. All children with internal rotational malalignment had greater ankle dorsiflexion and greater step width during running. Especially in active patients, this greater ankle dorsiflexion during running may result in overuse of the ankle dorsiflexor muscles, while greater step width may have beneficial effects in normalizing knee adduction moments. BACKGROUND Treadmills and rhythmic auditory cueing can influence stepping rhythm for individuals with Parkinson disease (PD). Of concern, however, is that auditory cueing directly addresses the temporal features of gait, whereas adjusting step length may be more important for people with PD. Stepping to a faster cadence when walking overground may increase gait speed, but without requiring an increased step length. Furthermore, given the potentially valuable role of walking on a treadmill for individuals with PD, we are concerned that increasing cadence with rhythmic auditory cueing while walking at a constant treadmill speed will induce even shorter steps. RESEARCH QUESTION What is the effect of different metronome cue frequencies on spatiotemporal gait parameters when walking overground compared to walking on a treadmill in people with PD? METHODS Using a repeated-measures design, 21 people with PD (stage 1-3) walked overground and on a treadmill with and without metronome cues of 85 %, 100 %, and 115 % of their baseline cadence frequency for one minute each. We assessed step length, and cadence during all conditions. Gait speed was assessed during overground gait. RESULTS An interaction effect between cue frequency and walking environment revealed that participants took longer steps during the 85 % condition on the treadmill only. When walking overground, metronome cues of 85 % and 115 % of baseline cadence yielded decreases and increases, respectively, in both cadence and gait speed with no associated change in step length. SIGNIFICANCE These data suggest that people with PD are able to alter spatiotemporal gait parameters immediately when provided the appropriate metronome cue and walking environment. We propose to target shortened step lengths by stepping to the beat of slow frequency auditory cues while walking on a treadmill, whereas the use of fast frequency cues during overground walking can facilitate faster walking speeds. BACKGROUND Programmed death ligand-1 (PD-L1) expression is related to the prognosis of many solid tumors; however, its prognostic value in oral squamous cell carcinoma (OSCC) remains unclear. Here, a meta-analysis was performed to estimate the association of PD-L1 expression with prognosis and clinicopathological features in patients with OSCC. METHODS PubMed, Web of Science, EMBASE, Cochrane Library, and CNKI databases were searched to find relevant studies for identification of the association of PD-L1 expression with clinicopathological features and overall survival (OS) in patients with OSCC. The strength of the association of PD-L1 expression with clinicopathological features and OS in patients with OSCC was assessed according to the relative risk (RR), hazard ratio (HR), and 95% confidence interval CI (CI). RESULT Twenty-three studies (including 3217 patients with OSCC) were evaluated. The meta-analysis showed that positive PD-L1 expression was significantly correlated with OS in patients with OSCC (HR = 1.